About Me

Chrome Key Bioinformatics is a solo consulting practice specializing in signal-noise separation for complex genomic data.

Hi, I'm Sam. I'm a computational biologist who loves turning messy data into clear insights.

My fascination with separating signal from noise started during my PhD at the University of Pennsylvania, where I developed greenscreen—a method for filtering artifacts from ChIP-seq data. The idea was simple but powerful: use existing tools creatively to remove the background obscuring your biological signal.

That philosophy shaped everything that followed. During my postdoc at Pfizer, I tackled complex datasets in internal medicine and rare disease research, always asking: what's real biology and what's technical noise? Before that, I worked at the NIH's National Human Genome Research Institute, and now I bring all that experience to clients as an independent contractor.

I founded Chrome Key Bioinformatics because I believe the best insights come from asking better questions—and from knowing what not to look at. Every dataset has a story, but you have to filter out the background first.

When I'm not analyzing data, I'm probably running through Cambridge or doing web development for Boston Women in Bioinformatics.

Fair warning: my two feline supervisors occasionally make guest appearances during video calls.